| Module Leaders |
Dr Tim Thomas |
|
Dr Anne Voss |
| Host Organisation |
Walter and Eliza Hall Institute |
Module description
Moz (MYST3/Kat6a) is a co-activator of transcription with histone acetyltransferase activity. Moz was originally identified in a recurrent translocation leading to acute myeloid leukaemia. It is a member of the MYST family of lysine acetyltransferases (Kats) and is closely related to a gene, Qkf (MYST4/Kat6b), which we have previously shown is essential for the maintenance of adult neural stem cells. Co-activators complexes are essential for regulating the activity of DNA binding transcription factors. These large multiprotein complexes typically contain an enzyme subunit that acts to modify chromatin structure and determine time/space
patterns of gene expression.
In order to determine the function of Moz during embryonic development we study a mutation in the Moz gene. We showed that Moz is essential for the formation of long term repopulating haematopoietic stem cells (HSC) during development. Surprisingly, the blood of Moz mutant animals is completely normal at birth, suggesting that Moz has a highly specific function in HSCs.
Module Leader biographies
Tim Thomas completed his Ph.D at Melbourne University. After post-doctoral positions in the Centre for Early Human Development at Monash Medical Centre and at the Max-Planck-Institute of Biophysical Chemistry in Göttingen, Germany, Tim established his laboratory at the Walter and Eliza Hall Institute of Medical Research in Melbourne in 2000. Tim is researching the transcriptional regulation of undifferentiated cell populations with particular emphasis on the regulation of chromatin structure both during embryonic development and in adult stem cell populations. Tim has published articles in Development, EMBO Journal, Genes & Development and Journal of Neuroscience.
Anne K. Voss completed her doctoral thesis in Hannover, Germany. After post-doctoral positions at Cornell University, Ithaca, NY, USA and at the Max-Planck-Institute of Biophysical Chemistry in Göttingen, Germany, Anne established her laboratory at the Walter and Eliza Hall Institute of Medical Research in Melbourne in 2000. Anne investigates the genetic regulation embryonic development and adult stem cells. On these topics Anne has published articles in Development, EMBO Journal, Genes & Development and Journal of Neuroscience.
Contact details
| Address |
Walter and Eliza Hall Institute,
1G Royal Parade,
Parkville, Victoria 3050
Australia |
| Phone |
+61 3 9345 2555
+61 3 9347 0852 |
| Web |
www.wehi.edu.au |
Selected publications
- Thomas T, Dixon MP, Kueh AJ, Voss AK.
Mof (MYST1, KAT8) is essential for progression of embryonic development past the blastocyst stage and required for normal chromatin architecture.Mol Cell Biol. 2008 Jun 9; [Epub ahead of print]
PMID: 18541669 [PubMed - as supplied by publisher]
- Voss AK, Britto JM, Dixon MP, Sheikh BN, Collin C, Tan SS, Thomas T.C3G regulates cortical neuron migration, preplate splitting and radial glial cell attachment.Development. 2008 Jun;135(12):2139-49
PMID: 18506028 [PubMed - in process]
- Merson TD, Dixon MP, Collin C, Rietze RL, Bartlett PF, Thomas T, Voss AK.
The transcriptional coactivator Querkopf controls adult neurogenesis.J Neurosci. 2006 Nov 1;26(44):11359-70
PMID: 17079664 [PubMed - indexed for MEDLINE]
- Voss AK, Krebs DL, Thomas T.C3G regulates the size of the cerebral cortex neural precursor population.EMBO J. 2006 Aug 9;25(15):3652-63
PMID: 16858399 [PubMed - indexed for MEDLINE]
- Thomas T, Corcoran LM, Gugasyan R, Dixon MP, Brodnicki T, Nutt SL, Metcalf D, Voss AK.
Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells.Genes Dev. 2006 May 1;20(9):1175-86
PMID: 16651658 [PubMed - indexed for MEDLINE]
- Voss AK, Gruss P, Thomas T.
The guanine nucleotide exchange factor C3G is necessary for the formation of focal adhesions and vascular maturation.Development. 2003 Jan;130(2):355-67
PMID: 12466202 [PubMed - indexed for MEDLINE]
- Voss AK, Thomas T, Petrou P, Anastassiadis K, Schöler H, Gruss P.
Taube nuss is a novel gene essential for the survival of pluripotent cells of early mouse embryos.Development. 2000 Dec;127(24):5449-61
PMID: 11076765 [PubMed - indexed for MEDLINE]
- Thomas T, Voss AK, Chowdhury K, Gruss P.
Querkopf, a MYST family histone acetyltransferase, is required for normal cerebral cortex development.Development. 2000 Jun;127(12):2537-48
PMID: 10821753 [PubMed - indexed for MEDLINE]
- Thomas T, Voss AK, Petrou P, Gruss P.The murine gene, Traube, is essential for the growth of preimplantation embryos.
Dev Biol. 2000 Nov 15;227(2):324-42
PMID: 11071758 [PubMed - indexed for MEDLINE]
- Voss AK*, Thomas, T*., Petrou, P., Anastassiadis, K., Schöler, H. and Gruss P. (2000). Taube Nuss is a novel gene essential for the survival of pluripotent cells of early mouse embryos. Development 127: 5449-5461